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SSAI contributes to consensus on reporting of ICU survivorship trials

August 11, 2017 by Administrator

SSAI and SCCTG (represented by Dr. Jon H Laake) has been part of a consensus process to create a core set of long-term outcome measures for studies on ICU survivors – improveLTO. The aim is to enable standard reporting of studies investigating ICU survivorship and the core sets should thus be used in all future studies investigating ICU survivorship.

This consensus work is now published (see citations below).

Below is a summary of the results:

1. Core Outcome Set (COS)

The panel recommended 8 core outcome domains:

  1. Survival
  2. Satisfaction with Life and Personal Enjoyment (Health-related Quality of Life)
  3. Mental health
  4. Pain
  5. Cognition
  6. Physical function
  7. Muscle and/or nerve function
  8. Pulmonary function

Citation:  Turnbull AE, Sepulveda KA, Dinglas VD, Bingham CO, Needham, DM.  Core domains for clinical research in acute respiratory failure survivors: an international modified Delphi consensus study.  Critical Care Medicine. 2017 Jun; 45(6):1001-1010. PubMed

2. Core Outcome Measurement Set (COMS) 

The following measurement instruments are recommended for the Core Outcomes from above:

  1. Satisfaction with Life and Personal Enjoyment (Health-related Quality of Life):  EQ-5D; Short Form-36 v2 (optional)
  2. Mental Health: Hospital Anxiety & Depression Scale,and Impact of Events Scale-Revised  (PTSD)
  3. Pain: EQ-5D Pain Question
  4. Cognition:  Montreal Cognitive Assessment-Blind (MoCA-Blind; optional)

Citation:  Needham DM, Sepulveda KA, Dinglas VD, Chessare CM, Friedman LA, Bingham III CO, Turnbull AE. Core outcome measures for clinical research in acute respiratory failure survivors: an international modified Delphi consensus study. Am J Respir Crit Care Med. 2017. ePub. PubMed

 

If you are planning a study that will evaluate patient outcomes after hospital discharge, please contact the improveLTO study group at improveLTO@jhmi.edu.  They can assist in the study and they have a VERY brief survey to evaluate use of the COMS.